Ontology highlight
ABSTRACT:
SUBMITTER: Gaohua L
PROVIDER: S-EPMC4625865 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Gaohua L L Wedagedera J J Small B G BG Almond L L Romero K K Hermann D D Hanna D D Jamei M M Gardner I I
CPT: pharmacometrics & systems pharmacology 20151009 10
Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in developing therapeutic regimens for TB. A physiologically based pharmacokinetic model incorporating a multicompartment permeability-limited lung model was developed and used to simulate plasma and pulmonary concentrations of seven drugs. Passive permeability of drugs within the lung was predicted using an in vitro-in vivo extrapolation approach. Simulated epithelial ...[more]