Ontology highlight
ABSTRACT:
SUBMITTER: Tavecchio M
PROVIDER: S-EPMC4626838 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Scientific reports 20151030
Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a potential role in bioenergetics is not understood. Here, we show that loss or depletion of CypD in cell lines and mice induces defects in mitochondrial bioenergetics due to impaired fatty acid β-oxidation. In turn, CypD loss triggers a global compensatory shift towards glycolysis, with transcriptional upregulation of effectors of glucose metabolism, increased glucose consumption and higher ATP production. In v ...[more]