Ontology highlight
ABSTRACT:
SUBMITTER: Das A
PROVIDER: S-EPMC4633824 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Das Avinash A Morley Michael M Moravec Christine S CS Tang W H W WH Hakonarson Hakon H Margulies Kenneth B KB Cappola Thomas P TP Jensen Shane S Hannenhalli Sridhar S
Nature communications 20151012
The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. We introduce a coupled Bayesian regression approach--eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies combination of regulatory single-nucleotide polymorphisms (SNPs) that explain the gene expression variance. On human heart data, eQTeL not only explains a significantly greater proportion of expressio ...[more]