Bat cells from Pteropus alecto are susceptible to influenza A virus infection and reassortment.
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ABSTRACT: Waterfowl are primary hosts for influenza A viruses (IAVs); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow-shouldered bats were shown to be hosts of an IAV, thereby constituting a potential novel reservoir. We show that Pteropus alecto kidney cells (PaKi) are susceptible to infection and sustain replication of A/WSN/33 (H1N1) and A/Vietnam/1203/04 (H5N1). Importantly, we show that co-infection of PaKi cells results in novel reassortants.
SUBMITTER: Dlugolenski D
PROVIDER: S-EPMC4634287 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
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