Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC4637879 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Zhang Tongshuai T Fang Shaohong S Wan Cong C Kong Qingfei Q Wang Guangyou G Wang Shuangshuang S Zhang Haoqiang H Zou Haifeng H Sun Bo B Sun Wei W Zhang Yao Y Mu Lili L Wang Jinghua J Wang Jing J Zhang Haiyu H Wang Dandan D Li Hulun H
Scientific reports 20151109
High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the disruption of blood-brain barrier (BBB) mediated by HSD is indirectly through enhancing blood pressure. The direct role of HSD on BBB integrity is unclear. Our purpose is to determine whether and how HSD might be involved in BBB breakdown during ischemia. To test that, we induced model of cerebral ischemia by permanent middle ce ...[more]