Ontology highlight
ABSTRACT:
SUBMITTER: Kanemaru K
PROVIDER: S-EPMC5442475 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Kanemaru Kaori K Nakamura Yoshikazu Y Totoki Kengo K Fukuyama Takatsugu T Shoji Madoka M Kaneko Hisae H Shiratori Kanako K Yoneda Atsuko A Inoue Takafumi T Iwakura Yoichiro Y Kabashima Kenji K Fukami Kiyoko K
Cell death and differentiation 20170421 6
Keratinocytes undergo a unique type of programmed cell death known as cornification, which leads to the formation of the stratum corneum (SC), the main physical barrier of the epidermis. A defective epidermal barrier is a hallmark of the two most common inflammatory skin disorders, psoriasis, and atopic dermatitis. However, the detailed molecular mechanisms of skin barrier formation are not yet fully understood. Here, we showed that downregulation of phospholipase C (PLC) δ1, a Ca<sup>2+</sup>-m ...[more]