Ontology highlight
ABSTRACT:
SUBMITTER: Cesarini E
PROVIDER: S-EPMC4639869 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Cesarini Elisa E Mozzetta Chiara C Marullo Fabrizia F Gregoretti Francesco F Gargiulo Annagiusi A Columbaro Marta M Cortesi Alice A Antonelli Laura L Di Pelino Simona S Squarzoni Stefano S Palacios Daniela D Zippo Alessio A Bodega Beatrice B Oliva Gennaro G Lanzuolo Chiara C
The Journal of cell biology 20151101 3
Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored. Key epigenetic regulators of development and differentiation are the Polycomb group (PcG) of proteins, organized in the nucleus as microscopically visible foci. Here, we show that lamin A/C is evolutionarily required for correct PcG protein nuclear comp ...[more]