Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC4639871 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
The Journal of cell biology 20151102 3
Cells must regulate the abundance and activity of numerous nutrient transporters in different organelle membranes to achieve nutrient homeostasis. As the recycling center and major storage organelle, lysosomes are essential for maintaining nutrient homeostasis. However, very little is known about mechanisms that govern the regulation of its membrane proteins. In this study, we demonstrated that changes of Zn(2+) levels trigger the downregulation of vacuolar Zn(2+) transporters. Low Zn(2+) levels ...[more]