Ontology highlight
ABSTRACT:
SUBMITTER: Kiseljak-Vassiliades K
PROVIDER: S-EPMC4641524 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Kiseljak-Vassiliades Katja K Xu Mei M Mills Taylor S TS Smith Elizabeth E EE Silveira Lori J LJ Lillehei Kevin O KO Kerr Janice M JM Kleinschmidt-DeMasters B K BK Wierman Margaret E ME
Molecular and cellular endocrinology 20150921
<h4>Purpose</h4>The aim of this study was to examine whether differential expression of somatostatin receptors (SSTR) 1-5 and downstream effectors are different in densely (DG) and sparsely (SG) granulated histological growth hormone (GH) pituitary tumor subtypes.<h4>Methods</h4>The study included 33 acromegalic patients with 23 DG and 10 SG tumors. SSTR1-5 were measured by qPCR and immunoblotting. Signaling candidates downstream of SSTR2 were also assessed.<h4>Results</h4>SSTR2 mRNA and protein ...[more]