Ontology highlight
ABSTRACT:
SUBMITTER: Schumacher N
PROVIDER: S-EPMC4646259 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Schumacher Neele N Meyer Dörte D Mauermann Andre A von der Heyde Jan J Wolf Janina J Schwarz Jeanette J Knittler Katharina K Murphy Gillian G Michalek Matthias M Garbers Christoph C Bartsch Jörg W JW Guo Songbo S Schacher Beate B Eickholz Peter P Chalaris Athena A Rose-John Stefan S Rabe Björn B
The Journal of biological chemistry 20150910 43
Generation of the soluble interleukin-6 receptor (sIL-6R) is a prerequisite for pathogenic IL-6 trans-signaling, which constitutes a distinct signaling pathway of the pleiotropic cytokine interleukin-6 (IL-6). Although in vitro experiments using ectopically overexpressed IL-6R and candidate proteases revealed major roles for the metalloproteinases ADAM10 and ADAM17 in IL-6R shedding, the identity of the protease(s) cleaving IL-6R in more physiological settings, or even in vivo, remains unknown. ...[more]