Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Valladares M
PROVIDER: S-EPMC4664896 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Hernandez-Valladares Maria M Prior Ian A IA
Scientific reports 20151201
Ras proteins are membrane bound signalling hubs that operate from both the cell surface and endomembrane compartments. However, the extent to which intracellular pools of Ras can contribute to cell signalling is debated. To address this, we have performed a global screen of compartmentalised Ras signalling. We find that whilst ER/Golgi- and endosomal-Ras only generate weak outputs, Ras localised to the mitochondria or Golgi significantly and distinctly influence both the abundance and phosphoryl ...[more]