Ontology highlight
ABSTRACT:
SUBMITTER: Sarett SM
PROVIDER: S-EPMC4665980 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Sarett Samantha M SM Nelson Christopher E CE Duvall Craig L CL
Journal of controlled release : official journal of the Controlled Release Society 20151101
The discovery of RNAi in the late 1990s unlocked a new realm of therapeutic possibilities by enabling potent and specific silencing of theoretically any desired genetic target. Better elucidation of the mechanism of action, the impact of chemical modifications that stabilize and reduce nonspecific effects of siRNA molecules, and the key design considerations for effective delivery systems has spurred progress toward developing clinically-successful siRNA therapies. A logical aim for initial siRN ...[more]