Ontology highlight
ABSTRACT:
SUBMITTER: Deutsch M
PROVIDER: S-EPMC4669705 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Deutsch M M Graffeo C S CS Rokosh R R Pansari M M Ochi A A Levie E M EM Van Heerden E E Tippens D M DM Greco S S Barilla R R Tomkötter L L Zambirinis C P CP Avanzi N N Gulati R R Pachter H L HL Torres-Hernandez A A Eisenthal A A Daley D D Miller G G
Cell death & disease 20150507
Necroptosis is a recently described Caspase 8-independent method of cell death that denotes organized cellular necrosis. The roles of RIP1 and RIP3 in mediating hepatocyte death from acute liver injury are incompletely defined. Effects of necroptosis blockade were studied by separately targeting RIP1 and RIP3 in diverse murine models of acute liver injury. Blockade of necroptosis had disparate effects on disease outcome depending on the precise etiology of liver injury and component of the necro ...[more]