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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation.

ABSTRACT: Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

SUBMITTER: Mitchell DE

PROVIDER: S-EPMC4672748 | biostudies-other | 2015 Aug

REPOSITORIES: biostudies-other

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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation.

Mitchell Daniel E DE Cameron Neil R NR Gibson Matthew I MI

Chemical communications (Cambridge, England) 20150801 65

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage. ...[more]

PMID: 26176027

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