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Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by Schwartz's reagent.

ABSTRACT: Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.

SUBMITTER: Ferrari V

PROVIDER: S-EPMC4673560 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by Schwartz's reagent.

Ferrari Valentina V Serpi Michaela M McGuigan Christopher C Pertusati Fabrizio F

Nucleosides, nucleotides & nucleic acids 20151022 11

Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry. ...[more]

PMID: 26492555

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