Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis.
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ABSTRACT:
SUBMITTER: Abdeen AA
PROVIDER: S-EPMC4675138 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Publications
Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis.
Abdeen Amr A AA Lee Junmin J Mo Samuel H SH Kilian Kristopher A KA
Journal of materials chemistry. B 20150806 40
The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues. ...[more]
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