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Aqueous synthesis of polyhedral "brick-like" iron oxide nanoparticles for hyperthermia and T2 MRI contrast enhancement.

ABSTRACT: A low temperature, aqueous synthesis of polyhedral iron oxide nanoparticles (IONPs) is presented. The modification of the co-precipitation hydrolysis method with Triton X surfactants results in the formation of crystalline polyhedral particles. The particles are herein termed iron oxide "nanobricks" (IONBs) as the variety of particles made are all variations on a simple "brick-like" rhombohedral shape as evaluated by TEM. These IONBs can be easily coated with hydrophilic silane ligands, allowing them to be dispersed in aqueous media. The dispersed particles are investigated for potential applications as hyperthermia and T2 MRI contrast agents. The results demonstrate that the IONBs perform better than comparable spherical IONPs in both applications, and show r2 values amongst the highest for iron oxide based materials reported in the literature.

SUBMITTER: Worden M 

PROVIDER: S-EPMC4675363 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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Aqueous synthesis of polyhedral "brick-like" iron oxide nanoparticles for hyperthermia and <i>T</i><sub>2</sub> MRI contrast enhancement.

Worden Matthew M   Bruckman Michael A MA   Kim Min-Ho MH   Steinmetz Nicole F NF   Kikkawa James M JM   LaSpina Catherine C   Hegmann Torsten T  

Journal of materials chemistry. B 20150804 34

A low temperature, aqueous synthesis of polyhedral iron oxide nanoparticles (IONPs) is presented. The modification of the co-precipitation hydrolysis method with Triton X surfactants results in the formation of crystalline polyhedral particles. The particles are herein termed iron oxide "nanobricks" (IONBs) as the variety of particles made are all variations on a simple "brick-like" rhombohedral shape as evaluated by TEM. These IONBs can be easily coated with hydrophilic silane ligands, allowing  ...[more]

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