Ontology highlight
ABSTRACT:
SUBMITTER: Saroufim MA
PROVIDER: S-EPMC4687876 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Saroufim Mark-Albert MA Bensidoun Pierre P Raymond Pascal P Rahman Samir S Krause Matthew R MR Oeffinger Marlene M Zenklusen Daniel D
The Journal of cell biology 20151201 6
After synthesis and transit through the nucleus, messenger RNAs (mRNAs) are exported to the cytoplasm through the nuclear pore complex (NPC). At the NPC, messenger ribonucleoproteins (mRNPs) first encounter the nuclear basket where mRNP rearrangements are thought to allow access to the transport channel. Here, we use single mRNA resolution live cell microscopy and subdiffraction particle tracking to follow individual mRNAs on their path toward the cytoplasm. We show that when reaching the nuclea ...[more]