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Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.

ABSTRACT: We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2(+/-) sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre). Pbx1/2 mutants have three salient molecular phenotypes of cortical regional and laminar organization: hypoplasia of the frontal cortex, ventral expansion of the dorsomedial cortex, and ventral expansion of Reelin expression in the cortical plate of the frontal cortex, concomitant with an inversion of cortical layering in the rostral cortex. Molecular analyses, including PBX ChIP-seq, provide evidence that PBX promotes frontal cortex identity by repressing genes that promote dorsocaudal fate.

SUBMITTER: Golonzhka O

PROVIDER: S-EPMC4688141 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.

Golonzhka Olga O Nord Alex A Tang Paul L F PLF Lindtner Susan S Ypsilanti Athena R AR Ferretti Elisabetta E Visel Axel A Selleri Licia L Rubenstein John L R JLR

Neuron 20151206 6

We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2(+/-) sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre). Pbx1/2 mutants have three salient molecular phenotypes of cortical regional and laminar organization: hypoplasia of the frontal cortex, ventral expansion of the dorsomedial cortex, and ventral expansion of Reelin expression in the cortical ...[more]

PMID: 26671461

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