Expansion of the Hox gene family and the evolution of chordates.
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ABSTRACT:
SUBMITTER: Pendleton JW
PROVIDER: S-EPMC46916 | biostudies-other | 1993 Jul
REPOSITORIES: biostudies-other
Publications
Expansion of the Hox gene family and the evolution of chordates.
Pendleton J W JW Nagai B K BK Murtha M T MT Ruddle F H FH
Proceedings of the National Academy of Sciences of the United States of America 19930701 13
Homeobox genes encode DNA-binding transcription regulators that participate in the formation of embryonic pattern or contribute to cell-type specificity during metazoan development. Homeobox genes that regulate axial patterning and segmental identity (Hox/HOM genes) share a conserved clustered genomic organization. Mammals have four clusters that have likely arisen from the duplication of a single ancestral cluster. The number of Hox-type genes in other deuterostomes was estimated by using a pol ...[more]
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