Ontology highlight
ABSTRACT:
SUBMITTER: Brannstrom M
PROVIDER: S-EPMC4695834 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Brännström Marie M Nordell Pär P Bonn Britta B Davis Andrew M AM Palmgren Anna-Pia AP Hilgendorf Constanze C Rubin Katarina K Grime Ken K
Pharmaceutics 20151215 4
Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For montelukast, no significant difference in cell uptake between HEK-OATP2B1 and empty vector cell lines was observed at pH 6.5 or pH 7.4, and no concentration-dependent uptake was detected. Montelukast ...[more]