Ontology highlight
ABSTRACT:
SUBMITTER: Ng K
PROVIDER: S-EPMC4698893 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Tetrahedron letters 20160101 3
Low temperature treatment of (ethoxyethynyl)lithium with epoxides or oxetanes in the presence of BF<sub>3</sub>•OEt<sub>2</sub>, followed by addition of aldehydes or ketones and warming to room temperature, affords structurally diverse five- and six-membered α-alkylidene and α-benzylidene lactones (<b>5</b>) in good to excellent yields. This one-pot process, in which three new carbon-carbon bonds and a ring are formed, affords substituted α,β-unsaturated lactones of predominantly <i>Z</i>-config ...[more]