Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration.
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ABSTRACT:
SUBMITTER: Zaritsky A
PROVIDER: S-EPMC4699880 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Publications
Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration.
Zaritsky Assaf A Welf Erik S ES Tseng Yun-Yu YY Angeles Rabadán M M Serra-Picamal Xavier X Trepat Xavier X Danuser Gaudenz G
Biophysical journal 20151201 12
We find how collective migration emerges from mechanical information transfer between cells. Local alignment of cell velocity and mechanical stress orientation-a phenomenon dubbed "plithotaxis"-plays a crucial role in inducing coordinated migration. Leader cells at the monolayer edge better align velocity and stress to migrate faster toward the open space. Local seeds of enhanced motion then generate stress on neighboring cells to guide their migration. Stress-induced motion propagates into the ...[more]
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