Ontology highlight
ABSTRACT:
SUBMITTER: Esteve C
PROVIDER: S-EPMC4705126 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Metabolomics : Official journal of the Metabolomic Society 20160108
The detection of small polar compounds such as amino neurotransmitters by MALDI mass spectrometry imaging has been hindered by low-detection sensitivity and background interferences. Recently, several of on-tissue chemical derivatization strategies have been independently reported that enable their detection. Here, we present a comparison between these methods, and demonstrate the visualization of the distributions of up to 23 amino metabolites in tissue. We applied this methodology to detect al ...[more]