Ontology highlight
ABSTRACT:
SUBMITTER: Biesecker LG
PROVIDER: S-EPMC47072 | biostudies-other | 1993 Aug
REPOSITORIES: biostudies-other
Biesecker L G LG Gottschalk L R LR Emerson S G SG
Proceedings of the National Academy of Sciences of the United States of America 19930801 15
Protein kinases transduce signals from extracellular ligands in the hematopoietic and other systems through direct phosphorylation of tyrosine, serine, or threonine residues. Little is known about the ligands and receptors that are important in the earliest stages of development--i.e., stem cell self-renewal and lineage commitment. We have made use of the lineage differentiation potential of the murine embryonic stem cell system to clone partial cDNAs encoding four putative protein kinases. Thre ...[more]