Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC4729817 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Zhu Saiyong S Russ Holger A HA Wang Xiaojing X Zhang Mingliang M Ma Tianhua T Xu Tao T Tang Shibing S Hebrok Matthias M Ding Sheng S
Nature communications 20160106
Pancreatic beta cells are of great interest for biomedical research and regenerative medicine. Here we show the conversion of human fibroblasts towards an endodermal cell fate by employing non-integrative episomal reprogramming factors in combination with specific growth factors and chemical compounds. On initial culture, converted definitive endodermal progenitor cells (cDE cells) are specified into posterior foregut-like progenitor cells (cPF cells). The cPF cells and their derivatives, pancre ...[more]