Ontology highlight
ABSTRACT:
SUBMITTER: McDonald PW
PROVIDER: S-EPMC4729877 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
McDonald Paul W PW Read Kaitlin A KA Baker Chandra E CE Anderson Ashlyn E AE Powell Michael D MD Ballesteros-Tato André A Oestreich Kenneth J KJ
Nature communications 20160108
The transcriptional repressor Bcl-6 is linked to the development of both CD4(+) T follicular helper (TFH) and central memory T (TCM) cells. Here, we demonstrate that in response to decreased IL-2 signalling, T helper 1 (TH1) cells upregulate Bcl-6 and co-initiate TFH- and TCM-like gene programs, including expression of the cytokine receptors IL-6Rα and IL-7R. Exposure of this potentially bi-potent cell population to IL-6 favours the TFH gene program, whereas IL-7 signalling represses TFH-associa ...[more]