Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5642489 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhang Shujie S Yu Ning N Wang Linfang L Liu Yanfeng Y Kong Yuying Y Liu Jing J Xie Youhua Y
Oncotarget 20170420 41
Interleukin-2 (IL-2) is critical for T lymphocyte activation and regulated by many transcriptional factors. Prospero-related homeobox 1 (Prox1) is a multifunctional transcription factor, which can work as either a transcriptional activator or repressor depending on the cellular and developmental environment. We previously reported the Prox1 expression in T cells, raising the possibility of Prox1 involvement in the regulation of T cell function and IL-2 production. Here we demonstrated that the P ...[more]