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Expanding and retracting from the self: Gains and costs in switching self-associations.

ABSTRACT: We report 2 experiments to assess the strength of forming and breaking associations to the self, familiar others, and unfamiliar others in a simple shape-label matching task. In each experiment, participants first formed shape-person associations (e.g., triangle-self). Subsequently, they had to relearn the associations with the shapes and labels rearranged (self→stranger in Experiment 1; self→friend in Experiment 2) and they carried out a matching task in which they judged whether shape-label stimuli were as newly instructed or re-paired. There were faster responses and fewer errors on match trials for newly formed self-associated stimuli. In contrast, after switching, reaction times were slower and accuracy was reduced on mismatch trials involving shapes previously associated with the self. The strength of the self-advantage in forming the new association on match trials correlated with the difficulty in switching from the old self-associated shape on mismatch trials. The results indicate that self-reference enhances the binding of associations in memory; this facilitates associations to new stimuli, but there is a cost of interference from old associations. (PsycINFO Database Record

SUBMITTER: Wang H

PROVIDER: S-EPMC4730907 | biostudies-other | 2016 Feb

REPOSITORIES: biostudies-other

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Project description:Ghana introduced rotavirus vaccine (ROTARIX 1-dose presentation) into the routine national immunization program in 2012 and switched to a different product (ROTAVAC 5-dose presentation) in 2020. ROTAVAC has a lower price per dose (US$0.85 versus US$2.15 for ROTARIX) and smaller cold chain footprint but requires more doses per regimen (three versus two). This study estimates the supply chain and service delivery costs associated with each product, the costs involved in switching products, and compares the cost-effectiveness of both products over the next ten years. We estimated the supply chain and service delivery costs associated with ROTARIX and ROTAVAC (evaluating both the 5-dose and 10-dose presentations) using primary data collected from health facilities in six of the 14 regions in the country. We estimated the costs of switching from ROTARIX to ROTAVAC using information collected from key informant interviews and financial records provided by the government. All costs were reported in 2020 US$. We used the UNIVAC decision-support model to evaluate the cost-effectiveness (US$ per disability-adjusted life-year (DALY) averted from government and societal perspectives) of ROTARIX and ROTAVAC (5-dose or 10-dose presentations) compared to no vaccination, and to each other, over a ten-year period (2020 to 2029). We ran probabilistic sensitivity analyses and other threshold analyses. The supply chain and service delivery economic cost per dose was $2.40 for ROTARIX, $1.81 for ROTAVAC 5-dose, and $1.76 for ROTAVAC 10-dose. The financial and economic cost of switching from ROTARIX to ROTAVAC 5-dose was $453,070 and $883,626, respectively. Compared to no vaccination, the cost per DALY averted was $360 for ROTARIX, $298 for ROTAVAC 5-dose, and $273 for ROTAVAC 10-dose. ROTAVAC 10-dose was the most cost-effective option and would be cost-effective at willingness-to-pay thresholds exceeding 0.12 times the national GDP per capita ($2,206 in the year 2020). The switch from ROTARIX to ROTAVAC 5-dose in 2020 was cost-saving. Rotavirus vaccination is highly cost-effective in Ghana. A switch from ROTAVAC 5-dose to ROTAVAC 10-dose would be cost-saving and should be considered.

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Expanding and retracting from the self: Gains and costs in switching self-associations.

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