Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC4731804 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Zhu Xiaoyu X Liu Xin X Cheng Zhongyi Z Zhu Jun J Xu Lei L Wang Fengsong F Qi Wulin W Yan Jiawei J Liu Ning N Sun Zimin Z Liu Huilan H Peng Xiaojun X Hao Yingchan Y Zheng Nan N Wu Quan Q
Scientific reports 20160129
Valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) are both HDAC inhibitors (HDACi). Previous studies indicated that both inhibitors show therapeutic effects on acute myeloid leukaemia (AML), while the differential impacts of the two different HDACi on AML treatment still remains elusive. In this study, using 3-plex SILAC based quantitative proteomics technique, anti-acetyllysine antibody based affinity enrichment, high resolution LC-MS/MS and intensive bioinformatic analysis, the qu ...[more]