Ontology highlight
ABSTRACT:
SUBMITTER: Robinson JE
PROVIDER: S-EPMC4737855 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Robinson J E JE Paluch J J Dickman D K DK Joiner W J WJ
Nature communications 20160127
It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons in Drosophila. Specifically, the vesicular glutamate transporter is upregulated, leading to over-activation of NMDA receptors, and the reserve pool of glut ...[more]