Ontology highlight
ABSTRACT:
SUBMITTER: Sarabdjitsingh RA
PROVIDER: S-EPMC4191766 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Sarabdjitsingh Ratna Angela RA Jezequel Julie J Pasricha Natasha N Mikasova Lenka L Kerkhofs Amber A Karst Henk H Groc Laurent L Joëls Marian M
Proceedings of the National Academy of Sciences of the United States of America 20140915 39
The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultradian pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on glutamatergic transmission is well documented, but it remains poorly understood how consecutive pulses impact on glutamate receptor trafficking and synaptic plasticity. By using high-resolution imaging and electrophysiological approaches, we report that a single pulse of CORT to hippocampal networks causes synaptic en ...[more]