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Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity.


ABSTRACT: The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultradian pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on glutamatergic transmission is well documented, but it remains poorly understood how consecutive pulses impact on glutamate receptor trafficking and synaptic plasticity. By using high-resolution imaging and electrophysiological approaches, we report that a single pulse of CORT to hippocampal networks causes synaptic enrichment of glutamate receptors and increased responses to spontaneously released glutamatergic vesicles, collectively abrogating the ability to subsequently induce synaptic long-term potentiation. Strikingly, a second pulse of CORT one hour after the first--mimicking ultradian pulses--completely normalizes all aspects of glutamate transmission investigated, restoring the plastic range of the synapse. The effect of the second pulse is precisely timed and depends on a nongenomic glucocorticoid receptor-dependent pathway. This normalizing effect through a sequence of CORT pulses--as seen around awakening--may ensure that hippocampal glutamatergic synapses remain fully responsive and able to encode new stress-related information when daily activities start.

SUBMITTER: Sarabdjitsingh RA 

PROVIDER: S-EPMC4191766 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity.

Sarabdjitsingh Ratna Angela RA   Jezequel Julie J   Pasricha Natasha N   Mikasova Lenka L   Kerkhofs Amber A   Karst Henk H   Groc Laurent L   Joëls Marian M  

Proceedings of the National Academy of Sciences of the United States of America 20140915 39


The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultradian pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on glutamatergic transmission is well documented, but it remains poorly understood how consecutive pulses impact on glutamate receptor trafficking and synaptic plasticity. By using high-resolution imaging and electrophysiological approaches, we report that a single pulse of CORT to hippocampal networks causes synaptic en  ...[more]

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