Ontology highlight
ABSTRACT:
SUBMITTER: Llanos S
PROVIDER: S-EPMC4740818 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Llanos Susana S García-Pedrero Juana M JM Morgado-Palacin Lucia L Rodrigo Juan P JP Serrano Manuel M
Nature communications 20160202
The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation. Accordingly, hyper-activation of mTORC1 results in phosphorylation of 4E-BP1 and stabilization of p21. In HNSCC, p21 levels strongly correlate with mTORC1 activity but not with p53 status. Finally, cl ...[more]