Ontology highlight
ABSTRACT:
SUBMITTER: Donly BC
PROVIDER: S-EPMC47449 | biostudies-other | 1993 Oct
REPOSITORIES: biostudies-other
Donly B C BC Ding Q Q Tobe S S SS Bendena W G WG
Proceedings of the National Academy of Sciences of the United States of America 19931001 19
Allatostatins (ASTs) are insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata. We have isolated a cDNA from the cockroach Diploptera punctata that encodes a 41.5-kDa precursor polypeptide containing the AST family of peptides. Translation of the cDNA revealed a 370-amino acid pre-pro-peptide consisting of 13 AST-type peptides and appropriate processing sites for endoproteolytic cleavage and amidation. The 13 potential AST sequences are characterized by the C-term ...[more]