Ontology highlight
ABSTRACT:
SUBMITTER: Johmura Y
PROVIDER: S-EPMC4754341 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Johmura Yoshikazu Y Sun Jia J Kitagawa Kyoko K Nakanishi Keiko K Kuno Toshiya T Naiki-Ito Aya A Sawada Yumi Y Miyamoto Tomomi T Okabe Atsushi A Aburatani Hiroyuki H Li ShengFan S Miyoshi Ichiro I Takahashi Satoru S Kitagawa Masatoshi M Nakanishi Makoto M
Nature communications 20160212
Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly established. We demonstrate here that SCF(Fbxo22)-KDM4A is a senescence-associated E3 ligase targeting methylated p53 for degradation. We find that Fbxo22 is highly expressed in senescent cells in a p53-dependent manner, and that SCF(Fbxo22) ubiquitylated p53 and formed a complex with a lysine de ...[more]