Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing.
Ontology highlight
ABSTRACT:
SUBMITTER: Ahn M
PROVIDER: S-EPMC4764838 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Publications
Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing.
Ahn Matae M Cui Jie J Irving Aaron T AT Wang Lin-Fa LF
Scientific reports 20160224
Recent genomic analysis of two bat species (Pteropus alecto and Myotis davidii) revealed the absence of the PYHIN gene family. This family is recognized as important immune sensors of intracellular self and foreign DNA and activators of the inflammasome and/or interferon pathways. Further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. Here we expanded genomic analysis of this gene family to include ten bat spec ...[more]
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