Ontology highlight
ABSTRACT:
SUBMITTER: Artzi N
PROVIDER: S-EPMC4767594 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Artzi Natalie N Tzafriri Abraham R AR Faucher Keith M KM Moodie Geoffrey G Albergo Theresa T Conroy Suzanne S Corbeil Scott S Martakos Paul P Virmani Renu R Edelman Elazer R ER
Annals of biomedical engineering 20150828 2
The long held assumption that sustained drug elution from stent coatings over weeks to months is imperative for clinical efficacy has limited the choice for stent coating materials. We developed and evaluated an omega-3 fatty acid (O3FA) based stent coating that is 85% absorbed and elutes 97% of its Sirolimus analog (Corolimus) load within 8d of implantation. O3FA coated stents sustained drug levels in porcine coronary arteries similarly to those achieved by slow-eluting durable coated Cypher Se ...[more]