Ontology highlight
ABSTRACT:
SUBMITTER: Maurin T
PROVIDER: S-EPMC4787806 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Maurin Thomas T Melko Mireille M Abekhoukh Sabiha S Khalfallah Olfa O Davidovic Laetitia L Jarjat Marielle M D'Antoni Simona S Catania Maria Vincenza MV Moine Hervé H Bechara Elias E Bardoni Barbara B
Nucleic acids research 20150806 17
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by the silencing of the FMR1 gene encoding an RNA-binding protein (FMRP) mainly involved in translational control. We characterized the interaction between FMRP and the mRNA of GRK4, a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase super-family, both in vitro and in vivo. While the mRNA level of GRK4 is unchanged in the absence or in the presence of FMRP in differe ...[more]