Ontology highlight
ABSTRACT:
SUBMITTER: Eshel D
PROVIDER: S-EPMC47944 | biostudies-other | 1993 Dec
REPOSITORIES: biostudies-other
Eshel D D Urrestarazu L A LA Vissers S S Jauniaux J C JC van Vliet-Reedijk J C JC Planta R J RJ Gibbons I R IR
Proceedings of the National Academy of Sciences of the United States of America 19931201 23
We have identified the gene DYN1, which encodes the heavy chain of cytoplasmic dynein in the yeast Saccharomyces cerevisiae. The predicted amino acid sequence (M(r) 471,305) reveals the presence of four P-loop motifs, as in all dyneins known so far, and has 28% overall identity to the dynein heavy chain of Dictyostelium [Koonce, M. P., Grissom, P. M. & McIntosh, J. R. (1992) J. Cell Biol. 119, 1597-1604] with 40% identity in the putative motor domain. Disruption of DYN1 causes misalignment of th ...[more]