Unknown

Dataset Information

0

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo.


ABSTRACT: BIBF 1120 is a potent triple angiokinase inhibitor now being evaluated in many types of tumors. We examine the antitumor effects of BIBF 1120 on nasopharyngeal carcinoma (NPC) in vitro and in vivo.The effect of BIBF 1120 on NPC cell proliferation was evaluated using the Cell Counting Kit 8 assay. The activities of BIBF 1120 as a single agent and in combination with cisplatin (DDP) in NPC tumor xenografts were evaluated by measuring microvessel density and expression of vascular endothelial growth factor signaling.BIBF 1120 exhibited limited inhibition of the growth of three NPC cell lines. Concurrent administration of BIBF 1120 and DDP provided greater antitumor effects compared to that observed with the use of either inhibitor as a single agent in the NPC xenograft model. Microvessel density and expression of vascular endothelial growth factor signaling were significantly reduced.BIBF 1120, either as a single agent or in combination with DDP, demonstrates significant antitumor and antiangiogenic effects in the NPC xenograft model. Our results indicate that BIBF 1120 administered in conjunction with chemotherapy might provide an effective treatment method for NPC.

SUBMITTER: Xue C 

PROVIDER: S-EPMC4801128 | biostudies-other | 2016

REPOSITORIES: biostudies-other

altmetric image

Publications

Efficacy of BIBF 1120 or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo.

Xue Cong C   Tian Ying Y   Zhang Jing J   Zhao Yuanyuan Y   Zhan Jianhua J   Fang Wenfeng W   Zhang Li L  

Drug design, development and therapy 20160315


<h4>Purpose</h4>BIBF 1120 is a potent triple angiokinase inhibitor now being evaluated in many types of tumors. We examine the antitumor effects of BIBF 1120 on nasopharyngeal carcinoma (NPC) in vitro and in vivo.<h4>Materials and methods</h4>The effect of BIBF 1120 on NPC cell proliferation was evaluated using the Cell Counting Kit 8 assay. The activities of BIBF 1120 as a single agent and in combination with cisplatin (DDP) in NPC tumor xenografts were evaluated by measuring microvessel densit  ...[more]

Similar Datasets

| S-EPMC7425654 | biostudies-literature
| S-EPMC8551620 | biostudies-literature
| S-EPMC7478529 | biostudies-literature
2021-04-14 | GSE132112 | GEO
| S-EPMC7871351 | biostudies-literature
| S-EPMC7498835 | biostudies-literature
| S-EPMC8023816 | biostudies-literature
| S-EPMC7319102 | biostudies-literature
| S-EPMC4493434 | biostudies-literature
| S-EPMC5111216 | biostudies-literature