Ontology highlight
ABSTRACT:
SUBMITTER: Xue C
PROVIDER: S-EPMC4801128 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Xue Cong C Tian Ying Y Zhang Jing J Zhao Yuanyuan Y Zhan Jianhua J Fang Wenfeng W Zhang Li L
Drug design, development and therapy 20160315
<h4>Purpose</h4>BIBF 1120 is a potent triple angiokinase inhibitor now being evaluated in many types of tumors. We examine the antitumor effects of BIBF 1120 on nasopharyngeal carcinoma (NPC) in vitro and in vivo.<h4>Materials and methods</h4>The effect of BIBF 1120 on NPC cell proliferation was evaluated using the Cell Counting Kit 8 assay. The activities of BIBF 1120 as a single agent and in combination with cisplatin (DDP) in NPC tumor xenografts were evaluated by measuring microvessel densit ...[more]