Ontology highlight
ABSTRACT:
SUBMITTER: Andrijauskaite K
PROVIDER: S-EPMC4807400 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Andrijauskaite K K Suriano S S Cloud C A CA Li M M Kesarwani P P Stefanik L S LS Moxley K M KM Salem M L ML Garrett-Mayer E E Paulos C M CM Mehrotra S S Kochenderfer J N JN Cole D J DJ Rubinstein M P MP
Cancer gene therapy 20150717 7
The ability to genetically modify T cells is a critical component to many immunotherapeutic strategies and research studies. However, the success of these approaches is often limited by transduction efficiency. As retroviral vectors require cell division for integration, transduction efficiency is dependent on the appropriate activation and culture conditions for T cells. Naive CD8(+) T cells, which are quiescent, must be first activated to induce cell division to allow genetic modification. To ...[more]