Ontology highlight
ABSTRACT:
SUBMITTER: Pegram HJ
PROVIDER: S-EPMC3359735 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Pegram Hollie J HJ Lee James C JC Hayman Erik G EG Imperato Gavin H GH Tedder Thomas F TF Sadelain Michel M Brentjens Renier J RJ
Blood 20120221 18
Adoptive cell therapy with tumor-targeted T cells is a promising approach to cancer therapy. Enhanced clinical outcome using this approach requires conditioning regimens with total body irradiation, lymphodepleting chemotherapy, and/or additional cytokine support. However, the need for prior conditioning precludes optimal application of this approach to a significant number of cancer patients intolerant to these regimens. Herein, we present preclinical studies demonstrating that treatment with C ...[more]