Ontology highlight
ABSTRACT:
SUBMITTER: Hrdinka M
PROVIDER: S-EPMC4819907 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Hrdinka Matous M Fiil Berthe Katrine BK Zucca Mattia M Leske Derek D Bagola Katrin K Yabal Monica M Elliott Paul R PR Damgaard Rune Busk RB Komander David D Jost Philipp J PJ Gyrd-Hansen Mads M
Cell reports 20160317 12
Innate immune signaling relies on the deposition of non-degradative polyubiquitin at receptor-signaling complexes, but how these ubiquitin modifications are regulated by deubiquitinases remains incompletely understood. Met1-linked ubiquitin (Met1-Ub) is assembled by the linear ubiquitin assembly complex (LUBAC), and this is counteracted by the Met1-Ub-specific deubiquitinase OTULIN, which binds to the catalytic LUBAC subunit HOIP. In this study, we report that HOIP also interacts with the deubiq ...[more]