Ontology highlight
ABSTRACT:
SUBMITTER: Dou Y
PROVIDER: S-EPMC5599799 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
The EMBO journal 20170829 18
Melanoma differentiation-associated protein 5 (MDA5) mediates the innate immune response to viral infection. Polymorphisms in <i>IFIH1</i>, the gene coding for MDA5, correlate with the risk of developing type 1 diabetes (T1D). Here, we demonstrate that MDA5 is crucial for the immune response to enteric rotavirus infection, a proposed etiological agent for T1D. MDA5 variants encoded by minor <i>IFIH1</i> alleles associated with lower T1D risk exhibit reduced activity against rotavirus infection. ...[more]