Ontology highlight
ABSTRACT:
SUBMITTER: Monzo P
PROVIDER: S-EPMC4831879 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Monzo Pascale P Chong Yuk Kien YK Guetta-Terrier Charlotte C Krishnasamy Anitha A Sathe Sharvari R SR Yim Evelyn K F EK Ng Wai Hoe WH Ang Beng Ti BT Tang Carol C Ladoux Benoit B Gauthier Nils C NC Sheetz Michael P MP
Molecular biology of the cell 20160224 8
Glioblastomas are extremely aggressive brain tumors with highly invasive properties. Brain linear tracks such as blood vessel walls constitute their main invasive routes. Here we analyze rat C6 and patient-derived glioma cell motility in vitro using micropatterned linear tracks to mimic blood vessels. On laminin-coated tracks (3-10 μm), these cells used an efficient saltatory mode of migration similar to their in vivo migration. This saltatory migration was also observed on larger tracks (50-400 ...[more]