Ontology highlight
ABSTRACT:
SUBMITTER: Frank V
PROVIDER: S-EPMC4832181 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Frank Viktoria V Kaufmann Stefan S Wright Rebecca R Horn Patrick P Yoshikawa Hiroshi Y HY Wuchter Patrick P Madsen Jeppe J Lewis Andrew L AL Armes Steven P SP Ho Anthony D AD Tanaka Motomu M
Scientific reports 20160415
Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environments of the marrow in vivo, we designed a novel surrogate substrate for marrow derived hMSCs based on physically cross-linked hydrogels whose elasticity can be adopted dynamically by chemical stimuli. Under frequent mechanical stress, hMSCs grown on our hydrog ...[more]