Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4833858 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Zhao Yiming Y Fay François F Hak Sjoerd S Manuel Perez-Aguilar Jose J Sanchez-Gaytan Brenda L BL Goode Brandon B Duivenvoorden Raphaël R de Lange Davies Catharina C Bjørkøy Astrid A Weinstein Harel H Fayad Zahi A ZA Pérez-Medina Carlos C Mulder Willem J M WJ
Nature communications 20160413
A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug-carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug-carrier compatibilit ...[more]