Ontology highlight
ABSTRACT:
SUBMITTER: Zang C
PROVIDER: S-EPMC4833864 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Nature communications 20160413
High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement (MANCIE) for bias correction and data integration of distinct genomic profiles on the same samples. MANCIE uses a Bayesian-supported principal component analysis-based approach to adjust the data so as to achieve better consistency between sample-wise distances in the different prof ...[more]