Ontology highlight
ABSTRACT:
SUBMITTER: Leite SC
PROVIDER: S-EPMC4838511 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Leite Sérgio Carvalho SC Sampaio Paula P Sousa Vera Filipe VF Nogueira-Rodrigues Joana J Pinto-Costa Rita R Peters Luanne Laurel LL Brites Pedro P Sousa Mónica Mendes MM
Cell reports 20160407 3
The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. α-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Using stimulated emission depletion super-resolution microscopy, we show that a periodic subcortical actin cytoskeleton is assembled in ev ...[more]