Ontology highlight
ABSTRACT:
SUBMITTER: Plutzky J
PROVIDER: S-EPMC48398 | biostudies-other | 1992 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19920201 3
Tyrosine phosphorylation is controlled by the opposing actions of tyrosine kinases and phosphotyrosine phosphatases (PTPs). src homology 2 domains (SH2) are found in several types of signaling proteins, including some tyrosine kinases. These domains bind phosphotyrosyl proteins and thus help promote signal transduction. Using mixed oligonucleotide-directed polymerase chain reactions, two previously undescribed rat PTP cDNA fragments were generated. Through subsequent screening of rat megakaryocy ...[more]